I'm having the same issue.  Would love a response.

We are using the 7.0.5 release.  We tried this on several computers including one at home to see if it was a network issue.  Same results.  We do a few clicks here or there, doesn't really matter and then ppt freezes completely.  At first it was working at snail speed and then freezing, but we resolved snail speed by putting presenter files on its on server.  After we put on a separate server it worked quicker but now after about 4-8 clicks system freezes and we have to ctrl alt delete.  Doing that obviously we loose all our changes.  This happens everytime.  We tried ppt and pptx files.  Now we are going to try loading ppt 2003 and if that doesn't help try using Presenter v6.  We are so sick of this product at this point.  If it doesn't work we will probably ask for our money back.  We are working with a rep from Adobe who we can't hardly understand and who states he can't replicate the problem.  Not sure how he can't replicate as we replicated on 3 pcs, one being at one of our IT techs home.....